Description
SNAP-8 Peptide, also known as Synaptosomal-Associated Protein 8 or Acetyl Octapeptide-3, is an advanced synthetic octapeptide that has gained attention in cosmetic and dermatological research for its potential anti-aging effects. It is an analog of the SNAP-25 protein, a key component in neurotransmitter release and cellular communication.
Scientific Overview
SNAP-8 is an eight-amino-acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂), acetylated at the N-terminus and amidated at the C-terminus for enhanced stability and bioactivity.
It was developed to compete with SNAP-25 in binding with vesicle-associated membrane proteins, which play a role in neurotransmitter release. By inhibiting this process, SNAP-8 can reduce acetylcholine release, leading to decreased muscle contractions—the same mechanism that causes fine lines and wrinkles to soften.
Research suggests that SNAP-8 may interact with Synaptotagmin 1 (Syt1) and the SNARE complex, interfering with calcium-mediated neurotransmission. This biochemical activity underpins its reputation as a topical peptide alternative to botulinum toxin (Botox®) in experimental cosmetic formulations.
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