Palmitoyl Tetrapeptide-7 (200mg)

Description

Palmitoyl Tetrapeptide-7

Molecular Formula: C₃₄H₆₂N₈O₇
Molecular Weight: 694.9 g/mol
Amino Acid Sequence: Palmitoyl-Gly-Gln-Arg-Pro
Other Names: Pal-Gly-Gln-Pro-Arg-OH, N-Palmitoylrigin, Palmitoyl-GQPR, Rigin
Form: Lyophilized powder
Use: Research and laboratory purposes only; not for human consumption

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Overview

Palmitoyl Tetrapeptide-7 is a synthetic tetrapeptide derived from natural matrikines, short peptides involved in extracellular matrix (ECM) regulation. It is designed to modulate ECM synthesis, inflammation, and cellular repair processes, particularly in skin tissue. Research indicates that it may stimulate collagen and elastin production, reduce pro-inflammatory cytokines such as interleukin-6 (IL-6), and modulate gene expression involved in ECM remodeling and skin integrity.

The peptide is often combined with Palmitoyl Oligopeptide (Matrixyl 3000) to enhance collagen stimulation and improve skin anti-aging outcomes.

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Chemical Properties

• Molecular Formula: C₃₄H₆₂N₈O₇

• Molecular Weight: 694.9 g/mol

• Other Names: Pal-Gly-Gln-Pro-Arg-OH, Palmitoyl-GQPR, N-Palmitoylrigin, Rigin

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Research and Preclinical Studies

Mechanism of Action

Palmitoyl Tetrapeptide-7 appears to function through several complementary mechanisms:

• ECM Stimulation: In animal and in vitro studies, the peptide enhances synthesis of key ECM components, including collagen (notably collagen VII), elastin, and laminins IV and V. These molecules are essential for the structural integrity of the dermal-epidermal junction and anchoring fibrils that stabilize skin architecture.

• Anti-inflammatory Effects: Palmitoyl Tetrapeptide-7 may suppress IL-6 secretion, a cytokine implicated in cellular aging, apoptosis, and inflammation. By reducing IL-6, the peptide helps protect ECM components from degradation and may improve skin resilience following environmental stress, such as UV exposure.

• Matrix Metalloproteinase (MMP) Inhibition: Research indicates that Palmitoyl Tetrapeptide-7 may downregulate MMP activity, preventing excessive ECM breakdown. This mechanism is relevant not only for skin maintenance but also for potential applications in oral tissue preservation, where MMP overactivity can lead to periodontitis or tissue damage.

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Skin Repair and Anti-Aging Potential

• Collagen VII Stimulation: Palmitoyl Tetrapeptide-7 selectively stimulates collagen type VII, critical for anchoring fibrils at the dermal-epidermal junction. This collagen type is vital for maintaining skin integrity, preventing blistering disorders, and supporting wound healing by reattaching epidermis to underlying dermal layers.

• Wrinkle Reduction and Elasticity Improvement: Clinical studies have investigated the peptide’s effect on human skin:

  • A 12-week double-blind, placebo-controlled study reported reduced wrinkle depth and length, alongside improvements in skin elasticity in participants using a Palmitoyl Tetrapeptide-7 cream.

  • Another study over four weeks reported reductions in fine wrinkles by 14%, elasticity improvements by 8–9%, and increases in dermal density by up to 28%, supporting the peptide’s role in rejuvenating aging skin.

• Synergy with Palmitoyl Oligopeptide: When combined with Palmitoyl Oligopeptide (Matrixyl 3000), Palmitoyl Tetrapeptide-7 exhibits synergistic stimulation of collagen synthesis and anti-inflammatory effects, enhancing skin texture, elasticity, and barrier function.

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Potential Applications

• Anti-aging skin formulations targeting wrinkle reduction, elasticity restoration, and dermal density enhancement

• Tissue repair and ECM preservation

• Possible adjunct for oral tissue protection, reducing ECM degradation and inflammation

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Conclusion

Palmitoyl Tetrapeptide-7 is a synthetic matrikine analog with demonstrated potential to:

• Stimulate collagen and elastin synthesis

• Reduce inflammatory cytokines like IL-6

• Modulate ECM and dermal-epidermal junction structure

• Enhance skin elasticity, dermal density, and reduce wrinkle depth

• Synergistically act with Palmitoyl Oligopeptide for enhanced anti-aging effects

It is strictly available for research purposes only, and its efficacy in humans is primarily supported by preclinical and preliminary clinical studies.

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References

1. National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 10078408, Palmitoyl Tetrapeptide-7.

2. Mondon P, Hillion M, et al. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology. J Cosmet Dermatol. 2015;14(2):152-160. doi:10.1111/jocd.12135

3. Sorsa T, Tjäderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004;10(6):311-318. doi:10.1111/j.1601-0825.2004.01038.x

4. Resende DI, et al. Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel). 2021;14(8):702. doi:10.3390/ph14080702

5. Salvador-Ferreira M, et al. Trending Anti-Aging Peptides. MDPI Journal. 2020;7(4):91

6. Hahn HJ, et al. Instrumental evaluation of anti‑aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E, and other ingredients. Exp Ther Med. 2016

7. Matrixyl 3000 (palmitoyl oligopeptide & palmitoyl tetrapeptide-7) synergy studies.