Gonadorelin (GnRH) (10mg)

Description

• Description
• Certificate of Analysis
• HPLC
• Mass Spectrometry

Gonadorelin Peptide is a synthetic analog of the naturally occurring gonadotropin-releasing hormone (GnRH), a key regulator of reproductive hormone secretion. In biological systems, GnRH plays a vital role in stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland—two hormones responsible for the proper function and maturation of the gonads.

Structurally composed of ten amino acids, Gonadorelin is chemically identical to natural GnRH and is therefore classified as a GnRH agonist. Its ability to mimic the endogenous hormone makes it a valuable tool in endocrine and reproductive research, allowing scientists to study the hypothalamic–pituitary–gonadal (HPG) axis, hormonal regulation, and gonadal function.

Gonadorelin’s action is thought to involve binding to GnRH receptors in the pituitary gland, triggering the synthesis and release of LH and FSH. However, extended exposure may lead to receptor downregulation, which can temporarily suppress gonadotropin secretion—a mechanism of interest in studies on hormonal modulation, fertility control, and anticarcinogenic pathways.

Chemical Information

• Molecular Formula: C₅₅H₇₅N₁₇O₁₃

• Molecular Weight: 1182.31 g/mol

• Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

• Synonyms: GnRH, LHRH, Gonadotropin-Releasing Hormone

Research Overview

Scientific research has explored Gonadorelin’s potential across several domains:

• Reproductive Function: Gonadorelin may help researchers investigate hypothalamic and pituitary signaling mechanisms and stimulate spermatogenesis in experimental models of hypothalamic dysfunction.

• Endocrine Recovery: It has been studied for its potential role in restoring hormonal balance after exogenous androgen exposure by reactivating the HPG axis.

• Cancer Research: Gonadorelin and related GnRH agonists have been examined for their potential to regulate hormone-dependent cancers by modulating estrogen and androgen levels.

• Neuroprotection: Preliminary studies indicate a possible link between GnRH analogs and brain health, particularly in reducing luteinizing hormone levels that may affect cognitive function.

• Diagnostics: Gonadorelin is also utilized in diagnostic testing to assess pituitary function and hormone responsiveness.

Key Findings from Research Studies

• In post-cycle recovery models, Gonadorelin has been observed to increase endogenous LH, FSH, and testosterone production after androgen suppression.

• Research in testicular function suggests that intermittent Gonadorelin exposure may successfully stimulate spermatogenesis in hypothalamic dysfunction models.

• Studies on cancer models indicate that Gonadorelin may reduce exposure to estrogenic mitogens, potentially lowering cancer cell proliferation risk.

• Investigations into neurological impact propose that selective modulation of LH through GnRH analogs could support brain health and reduce cognitive decline.

Intended Use

Gonadorelin Peptide is provided strictly for research and laboratory use only.
It is not intended for human consumption, veterinary, or therapeutic purposes. Researchers must adhere to appropriate handling and storage protocols in accordance with laboratory safety standards.