GHK-Cu (200mg)

Description

GHK-Cu Peptide (Copper Tripeptide-1) is a naturally occurring copper complex consisting of the tripeptide glycyl-L-histidyl-L-lysine (GHK) bound to a copper (II) ion. This complex plays an important role in numerous biological repair and regeneration processes. Research suggests that GHK-Cu may help stimulate collagen and elastin synthesis, support wound healing, and promote antioxidant and anti-inflammatory actions that protect cells against oxidative damage.

The peptide’s natural affinity for copper ions allows it to deliver copper directly to cells, where it may assist in enzymatic processes essential for tissue regeneration, angiogenesis, and immune response regulation. Scientists have long been interested in GHK-Cu for its potential influence on skin rejuvenation, connective tissue repair, and cell communication within the extracellular matrix.

Chemical Makeup

• Molecular Formula: C₁₄H₂₃CuN₆O₄

• Molecular Weight: 340.38 g/mol

• Synonyms: Cu-GHK, Copper Tripeptide-1, 6BJQ43T1I9

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Research Overview

GHK-Cu and Collagen Synthesis

Studies indicate that GHK-Cu may stimulate fibroblast activity and collagen production, possibly by mimicking peptide sequences derived from collagen breakdown. One study by Maquart et al. (1988) demonstrated that GHK-Cu can increase collagen synthesis in fibroblast cultures, suggesting its importance in tissue repair and regeneration.
Further research also proposes that combining GHK-Cu with hyaluronic acid (HA) may enhance collagen IV production through synergistic biological mechanisms, improving dermal structure, elasticity, and hydration (Jiang et al., 2023).

GHK-Cu and Wound Healing

Scientific models indicate that GHK-Cu may accelerate wound closure and reduce inflammation. In ischemic wound models, GHK-Cu reportedly lowered inflammatory cytokines such as TNF-α and decreased matrix metalloproteinases (MMP-2 and MMP-9), both linked to tissue degradation.
Clinical studies involving diabetic ulcers have shown faster wound healing and a reduced infection rate (7% vs 34% in control groups) when GHK-Cu was used alongside standard care (Mulder et al., 1994).

GHK-Cu and Antioxidant Activity

GHK-Cu may play a role in neutralizing reactive oxygen species (ROS) and other harmful radicals (RNS, RCS) responsible for oxidative tissue damage. It has been observed to reduce iron release from ferritin by up to 87%, minimizing oxidative stress in damaged tissues (Cebrián et al., 2005). These antioxidant properties may also support tissue preservation and regeneration.

GHK-Cu and Skin Health

In cosmetic and dermatological research models, GHK-Cu appears to improve skin density, elasticity, and hydration. Multiple studies have noted visible reductions in fine lines, wrinkles, and photodamage, suggesting that the peptide may stimulate keratinocyte proliferation, collagen remodeling, and skin firmness. Over 12 weeks, GHK-Cu demonstrated improved epidermal thickness, clarity, and pigmentation balance, outperforming standard treatments such as vitamin K and retinoids (Abdulghani et al., 1998; Pickart et al., 2015).

GHK-Cu and Inflammation Control

Research also suggests that GHK-Cu may modulate inflammatory signaling pathways such as NF-κB and p38 MAPK, leading to reduced cytokine production and improved tissue recovery in inflamed or damaged models (Liu et al., 2022). This anti-inflammatory potential may contribute to its protective effects in lung and vascular tissues.

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Certificate of Analysis (COA)

Each batch of GHK-Cu Peptide is rigorously tested to confirm identity, purity, and molecular integrity. The COA includes analytical verification through HPLC and Mass Spectrometry to ensure >99% purity and research-grade consistency.

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HPLC

High-Performance Liquid Chromatography (HPLC) analysis confirms that GHK-Cu consistently meets or exceeds 99% purity, ensuring the absence of contaminants and degradation products. This guarantees high-quality peptide material suitable for precise and reproducible experimental applications.

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Mass Spectrometry

Mass Spectrometry testing confirms the molecular weight (340.38 g/mol) and verifies the accurate amino acid sequence of GHK-Cu (Gly-His-Lys), ensuring the authenticity and stability of the peptide-copper complex.

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Intended Use

GHK-Cu Peptide is offered strictly for research and laboratory use only.
It is not intended for human consumption, therapeutic use, or veterinary applications. Researchers should handle the peptide following standard laboratory safety guidelines and institutional protocols.

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References

1. Maquart FX et al. FEBS Letters (1988) 238(2):343–346.

2. Abdulghani AA et al. Disease Management and Clinical Outcomes (1998) 4(1):136–141.

3. Jiang F et al. J Cosmet Dermatol (2023) 22(9):2598–2604.

4. Canapp SO Jr et al. Veterinary Surgery (2003) 32(6):515–523.

5. Mulder GD et al. Wound Repair Regen (1994) 2(4):259–269.

6. Gul NY et al. Veterinary Dermatology (2008) 19(1):7–14.

7. Alven S et al. Polymers (2022) 14(4):724.

8. Cebrián J et al. Int J Cosmetic Sci (2005) 27(5):271–278.