Description
Cardiogen Peptide (H-Ala-Glu-Asp-Arg-OH)
Overview
Cardiogen is a synthetic tetrapeptide considered a peptide bioregulator that may influence cardiovascular tissues, fibroblast activity, and tumor cell dynamics. Research suggests that Cardiogen may stimulate cardiomyocyte proliferation, reduce apoptosis in heart tissue, and regulate fibroblast activity, which may contribute to scar formation modulation and improved tissue repair. It is also being investigated for its potential anti-tumor and anti-aging effects.
Chemical Information
Molecular Formula: C18H31N7O9
Molecular Weight: 489.5 g/mol
Structure: H-Ala-Glu-Asp-Arg-OH
Other Titles: SCHEMBL3194515
Research and Mechanisms of Action
1. Cardiogen and Cardiomyocyte Proliferation
Experimental studies suggest that Cardiogen may increase the proliferation of cardiomyocytes in both young and aged tissue models. This effect is associated with upregulation of cytoskeletal proteins (actin, vimentin, tubulin) and nuclear matrix proteins (lamin A and C), which are essential for cell structure, intracellular transport, and gene regulation. By potentially influencing DNA accessibility and transcription of key growth-related genes, Cardiogen may enhance cell growth and differentiation in myocardial tissue.
2. Cardiogen and Cardiomyocyte Apoptosis
Cardiogen appears to reduce the expression of the p53 gene, which may lower apoptosis rates in cardiomyocytes after injury. Studies in experimental murine models of myocardial ischemia showed a threefold reduction in mortality, decreased necrotic areas, preserved myocardial glycogen, and potential mitochondrial protection, suggesting improved survival and function of cardiomyocytes post-injury. Cardiogen may also stimulate reparative mechanisms in ischemic tissue, potentially supporting cardiac remodeling.
3. Cardiogen and Fibroblasts
Research suggests that Cardiogen may regulate fibroblast activity, particularly in aged or senescent cells, by restoring signaling factors involved in fibroblast differentiation. This may contribute to improved tissue homeostasis and potentially reduce excessive scar formation during cardiac repair.
4. Cardiogen and Tumor Cells
Interestingly, Cardiogen exhibits differential effects on tumor cells, particularly in M-1 sarcoma models. While it promotes cardiac tissue survival, it may stimulate apoptosis in tumor cells and induce hemorrhagic necrosis. Tumor growth inhibition seems to be mediated via vascular mechanisms, rather than a direct cytostatic effect, suggesting a targeted anti-tumor potential related to aberrant tumor vasculature.
5. Cardiogen and Anti-Aging / Tissue Support
Cardiogen may enhance cellular metabolism and protein expression in aging tissues. By upregulating cytoskeletal and nuclear matrix proteins and reducing apoptosis, the peptide has been investigated as a potential anti-aging therapeutic in cardiac and fibroblast cell populations.
Potential Research Applications
Cardiovascular repair and cardiomyocyte protection
Modulation of fibroblast activity to control scar formation
Anti-tumor research focusing on tumor apoptosis and vascular targeting
Anti-aging studies in senescent cardiac or prostate cells
Cardiac remodeling and recovery after ischemic injury
Note: Cardiogen peptide is for research use only. Its safety, efficacy, and pharmacological applications in humans have not been fully established.
References:
Levdik NV, Knyazkin IV. Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. Bull Exp Biol Med. 2009;148(3):433-436.
Kheĭfets OV, Poliakova VO, Kvetnoĭ IM. Peptidergic regulation of fibroblast differentiation in aging prostate cells. Adv Gerontol. 2010;23(1):68-70.
Khavinson VK, Lin’kova NS, et al. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med. 2012;153(4):559-562.
Additional supporting in vitro and in vivo studies on cardiomyocyte proliferation and apoptosis.
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