BPC-157 & TB-500 Blend (10mg)

Description

BPC-157 & TB-500 Peptide Blend

Overview
The BPC-157 & TB-500 peptide blend combines two synthetic peptides that have been extensively studied for their potential tissue repair, regenerative, and anti-inflammatory properties. BPC-157, a 15-amino-acid peptide, is derived from a protective protein found in the gastric mucosa, while TB-500, a 43-amino-acid peptide, is a synthetic analog of thymosin beta-4. Both peptides appear to influence cellular signaling pathways, angiogenesis, and tissue regeneration. When combined, their potential actions on tissue repair, cellular motility, and wound healing may be enhanced, potentially producing faster and more robust regenerative effects than when used individually.

Chemical Information

• BPC-157: C62H98N16O22, MW 1419.5 g/mol

• TB-500: C212H350N56O78S, MW 4963 g/mol

• Other Titles: Body Protection Compound-157 (BPC-157), Thymosin Beta-4 (TB-500)

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Research and Mechanisms of Action

1. Tissue Repair and Wound Healing

• BPC-157 has been suggested to promote angiogenesis, collagen formation, and extracellular matrix assembly, contributing to accelerated wound repair in experimental models. It may also influence nitric oxide production, inflammatory cytokines, and growth factors to facilitate tissue regeneration.

• TB-500 appears to regulate actin cytoskeleton dynamics, sequestering G-actin to enhance cellular motility, a key mechanism in wound healing. Research also indicates TB-500 may upregulate miR-146a, which potentially suppresses inflammatory pathways (IRAK1 and TRAF6) to reduce tissue inflammation.

2. Ligament and Tendon Repair

• Studies on transected murine medial collateral ligaments (MCL) have shown that TB-500 promotes evenly spaced and wider collagen fibers, improving mechanical properties of regenerating tissue.

• BPC-157 may enhance tendon fibroblast migration and resilience to oxidative stress, possibly via F-actin formation and the FAK-paxillin pathway, contributing to faster and more organized tendon repair.

3. Muscle Regeneration

• BPC-157 has been demonstrated to aid in the recovery of damaged gastrocnemius muscle, restoring both structure and function in experimental models, even under corticosteroid-induced injury.

• TB-500 may improve cardiac muscle resilience, supporting angiogenesis and early cardiomyocyte survival under hypoxic conditions. It may also enhance myocardial cell migration and activate kinases such as ILK and Akt/PKB, which are important for cell survival and regeneration.

4. Nervous System and Anti-Inflammatory Effects

• BPC-157 may interact with pathways involved in nerve tissue repair, while both peptides are implicated in modulating inflammatory responses, reducing cytokine-mediated damage, and supporting tissue homeostasis.

5. Combined Potential

• While there are no studies directly combining BPC-157 and TB-500, the theoretical synergy suggests that their combined use could accelerate healing, angiogenesis, and tissue regeneration across multiple tissue types including muscle, tendon, ligament, and nerve tissues.

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Key Research Highlights

1. TB-500 enhanced re-epithelialization in wounded murine models by 41% and promoted wound contraction over 7 days.

2. BPC-157 demonstrated increased collagen deposition and angiogenesis in murine wound models, supporting faster tissue recovery.

3. Ligament Repair: TB-500 improved collagen structure and mechanical properties in MCL transections.

4. Muscle Regeneration: BPC-157 restored gastrocnemius muscle function post-injury; TB-500 enhanced myocardial resilience and early cardiomyocyte survival.

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Applications for Research

• Experimental tissue regeneration

• Ligament, tendon, and muscle repair

• Wound healing studies

• Anti-inflammatory and cytoprotective research

• Cardiac and neurological tissue repair

Note: This peptide blend is for research use only. Safety and efficacy in humans have not been fully established.

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References

1. Seiwerth, S., et al. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Front. Pharmacol., 12, 627533. https://doi.org/10.3389/fphar.2021.627533

2. Maar, K., et al. (2021). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind Adult Organs of Their Embryonic State. Cells, 10(6), 1343. https://doi.org/10.3390/cells10061343

3. PubChem Compound Summary: BPC-157, TB-500